1. Issues with „intersex“ : birth defects so alpha emitters (mostly)
2. Endocrine disruption by alpha emitting nanoparticulates (mostly) causing hormone changes
3. self-repression of the innate bisexuality in most people leads many cowards to play with the „frail“, those exhibiting „weakness“, bringing them into the decision to undertake sex change because 2. and 3. at least combine.
Then of course we understand people who decide surgery might regret the decision !